2. Signaling Pathways
  3. Anti-infection
  4. Parasite

Parasite

Parasite

Related Products

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Antiparasitics are a class of medications which are indicated for the treatment of parasitic diseases such as nematodes, cestodes, trematodes, and infectious protozoa.

Parasite Isoform Specific Products:

Parasite Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-N0059R
    D-Arabinose (Standard)
    		Inhibitor
    D-Arabinose (Standard) is the analytical standard of D-Arabinose. This product is intended for research and analytical applications. D-Arabinose is is an orally active antidepressant and a growth inhibitor of C. elegans (IC50 is 7.5 mM). D-Arabinose can penetrate the blood-brain barrier, selectively interfere with the metabolism of D-ribose and D-fructose, and inhibit the growth of nematodes. D-Arabinose can also inhibit the synthesis of cell biofilm and exert antibacterial activity. D-Arabinose activates the ACSS2-PPARγ/TFEB-CRTC1 axis through the lysosomal AXIN-LKB1-AMPK pathway, inducing CRTC1 transcription, exerts antidepressant-like activity. D-Arabinose is the ring-opened form of the aldopentose D-?Arabinose (HY-N7082).
    D-Arabinose (Standard)
  • HY-128268
    PFK-IN-1
    PFK-IN-1 (compound 1) is a phosphofructokinase (PFK) inhibitor, with IC50 values of 0.41 and 0.23 μM against T.brucei and T.cruzi PFK, respectively, and an ED50 of 15.18 μg/mL for T.brucei. The half-lives of PFK-IN-1 in rat and mouse liver microsomes are 9.7 and 408 minutes, respectively.
    PFK-IN-1
  • HY-146109
    RyRs activator 1
    RyRs activator 1 (compound 7f) is a potent activator of ryanodine receptors (RyRs). RyRs activator 1 at 0.5 mg/L displays 100% larvicidal activity. The larvicidal activity of RyRs activator 1 is 90% at 0.01 mg/L.
    RyRs activator 1
  • HY-N13197
    6-Methyl-5,6-dihydro-2H-pyran-2-one
    		Inhibitor
    6-Methyl-5,6-dihydro-2H-pyran-2-one is a heterocyclic compound with antitumor, antifungal, antimicrobial, anti-inflammatory, antistress, antibiotic, antituberculosis, antiparasitic, antiviral activities.
    6-Methyl-5,6-dihydro-2H-pyran-2-one
  • HY-N10928
    Lettowienolide
    		Inhibitor
    Lettowienolide, a geranylbenzoquinonoid, exhibits mild in vitro activity against the Plasmodium falciparum malaria parasite (IC50~20 μg/mL).
    Lettowienolide
  • HY-12643R
    Eprinomectin (Standard)
    		Inhibitor
    Eprinomectin (Standard) is the analytical standard of Eprinomectin. This product is intended for research and analytical applications. Eprinomectin is a type of avermectin. Eprinomectin, as a broad-spectrum fungicide, has insecticidal, insecticidal and acaricidal activities. Eprinomectin induces apoptosis and autophagy in prostate cancer cells and has antitumor activity.
    Eprinomectin (Standard)
  • HY-118865
    Piperaquine tetraphosphate
    		Inhibitor
    Piperaquine tetraphosphate is a potent antimalaria agent. Piperaquine tetraphosphate shows inhibition for chloroquine-sensitive and the chloroquine-resistant isolates. Piperaquine tetraphosphate in combination with dihydroartemisinin has the potential for the research of chloroquine-resistant malaria.
    Piperaquine tetraphosphate
  • HY-P5694
    Human α-defensin 5
    		Inhibitor
    Human α-defensin 5 is an antiviral peptide. Human α-defensin 5 blocks infection of non-enveloped viruses, including AdV, HPV, and polyomaviruses (IC50: 0.6-1.25 μM for HPV16). Human α-defensin 5 can bind to the viral capsid and blocks escape of the virus from the endosome. Human α-defensin 5 increases HIV binding to the cell surface. Human α-defensin 5 also has parasiticidal activity.
    Human α-defensin 5
  • HY-B2015S
    Carbosulfan-d18
    		Inhibitor
    Carbosulfan-d18 is the deuterium labeled Carbosulfan. Carbosulfan inhibited relatively potently CYP3A4 and moderately CYP1A1/2 and CYP2C19 in pooled HLM (human livers). Carbosulfan activation is predominantly catalyzed in humans by CYP3A4.
    Carbosulfan-d<sub>18</sub>
  • HY-147933
    Antitrypanosomal agent 8
    		Inhibitor
    Antitrypanosomal agent 8 (compound 3b) has potent antitrypanosomal activity against Trypanosoma brucei with an IC50 value of 0.79 μM and exhibits certain cytotoxicity in L6 cells (IC50=80.95 μM).
    Antitrypanosomal agent 8
  • HY-149939
    Antimalarial agent 26
    		Inhibitor
    Antimalarial agent 26 is an orally active 1,4-naphthoquinones derivative with antimalarial activities. Antimalarial agent 26 shows cytotoxicity against P. falciparum and selectivity over mammalian cell lines. Antimalarial agent 26 inhibits P. burghei induced parasitemia in vivo.
    Antimalarial agent 26
  • HY-N1480S1
    (-)-Fucose-13C-1
    (-)-Fucose-13C-1 is the 13C labeled (-)-Fucose. (-)-Fucose is classified as a member of the hexoses, plays a role in A and B blood group antigen substructure determination, selectin-mediated leukocyte-endothelial adhesion, and host-microbe interacti[
    (-)-Fucose-<sup>13</sup>C-1
  • HY-B0978S
    Diethyltoluamide-d10
    Diethyltoluamide-d10 is the deuterium labeled Diethyltoluamide. Diethyltoluamide is the most common active ingredient in insect repellents. It is intended to provide protection against mosquitoes, ticks, fleas, chiggers, leeches, and many other biting insects.
    Diethyltoluamide-d<sub>10</sub>
  • HY-155301
    Antileishmanial agent-24
    		Inhibitor
    Antileishmanial agent-24 (compound 33) is an antileishmanial agent with an IC50 of 5.39 μM against amastigote.
    Antileishmanial agent-24
  • HY-146044
    Antiparasitic agent-6
    		Inhibitor
    Antiparasitic agent-6 (compound 5b) has selectively antiparasitic activity against Leishmania infantum (L. infantum) with an IC50 value of 3.89 μM. Antiparasitic agent-6 also has certain cytotoxicity against HepG2 (CC50 = 13.64 μM).
    Antiparasitic agent-6
  • HY-119688
    Amabiline
    		Inhibitor
    Amabiline is a compound isolated from a plant that contains a variety of bioactive ingredients including Amabiline. The plant as a whole has a variety of traditional uses and also has certain pharmacological activity and toxicity.
    Amabiline
  • HY-B0744BR
    Eflornithine hydrochloride hydrate (Standard)
    		Inhibitor
    Eflornithine (hydrochloride hydrate) (Standard) is the analytical standard of Eflornithine (hydrochloride hydrate). This product is intended for research and analytical applications. Eflornithine hydrochloride hydrate (DFMO hydrochloride hydrate) is a specific, irreversible inhibitor of the enzyme ornithine decarboxylase. Eflornithine hydrochloride hydrate is a medication for the treatment of African trypanosomiasis and excessive facial hair growth in women.
    Eflornithine hydrochloride hydrate (Standard)
  • HY-144294
    Purine phosphoribosyltransferase-IN-1
    		Inhibitor
    Purine phosphoribosyltransferase-IN-1 (Compound (S,R)-48) is a potent inhibitor of the Plasmodium falciparum (Pf), P. vivax (Pv) and Trypanosoma brucei (Tbr) 6-oxopurine purine phosphoribosyltransferases (PRTs), with Ki values of 50, 20, and 2 nM, respectively.
    Purine phosphoribosyltransferase-IN-1
  • HY-158776
    SLU-10482
    		Inhibitor
    SLU-10482 is an orally active anti-parasitic agent, that inhibits Cryptosporidium parvum with an IC50 of 0.0687 μM. SLU-10482 exhibits anti-infective efficacy in C. parvum infected mice with an AC50 of 0.0686 μM.
    SLU-10482
  • HY-168862
    Insecticidal agent 18
    		Inhibitor
    Insecticidal agent 18 (compound 34) is a potent insecticidal agent. Insecticidal agent 18 shows acaricidal activity.
    Insecticidal agent 18
Parasite Isoform Comparison

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